h-hydrogen

Background: The correlation intermediary hemoglobin A_1c (Hb A_1c) and imperil for complications in diabetic patients heightens the requisite to be up to snuff Hb A_1c with correctness. We evaluated the in the know behaviour for measuring Hb A_1c in the Asian and Pacific field by examining text submitted by laboratories participating in the Taiwan proficiency-testing program.

Methods: Five fresh-pooled blood samples were sent to participating laboratories twice each year. The results were evaluated against butt values assigned by the Nationalist Glycohemoglobin Standardization Program network laboratories; a slipping away criterion of ±7% of the objective value was acclimatized. Commensuration uncertainty at Hb A_1c concentrations of 7.0% and 8.0% were steady.

Results: A whole of 276 laboratories from 11 countries took vicinage in the Hb A_1c examine. At the Hb A_1c concentrations tested method-specific interlaboratory imprecision (CVs) were 1.1%–13.9% in 2005, 1.3%–10.1% in 2006, 1.2%–8.2% in 2007, and 1.1%–6.1% in 2008. Differences middleman goal values and median values from the commonly inured to methods ranged from –0.24% to 0.22% Hb A_1c in 2008. In 2005 83% of laboratories passed the survey, and in 2008 93% passed. At 7.0% Hb A_1c, magnitude uncertainty was on mediocre 0.49% Hb A_1c.

Conclusions: The use of accuracy-based competence testing with stringent superiority criteria has improved the about of Hb A_1c testing in the Asian and Pacific laboratories during the 4 years of assessment.