Archive for the ‘Other Areas of Clinical Chemistry’ Category
Eleftherios Diamandis Elected a Fellow of the AAAS [News & Views]
Written by on March 28, 2012 – 7:01 pm -Tags: chemistry, clinic
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The Heart Is Both Hot and Cold [Unveiling the Right Side]
Written by Greene, D. N. on March 28, 2012 – 7:01 pm -Tags: chemistry, clinic
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On Storms, Ships, and Railways. J.M.W. Turner [Science in the Arts]
Written by Dominiczak, M. H. on March 28, 2012 – 7:01 pm -Tags: chemistry, clinic
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Correction [Correction]
Written by on February 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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Reviewing for Newbies: A Brief Guide for the Rookie Peer Reviewer [News & Views]
Written by Peake, R. W. A. on February 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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White Winter Scene after Heavy Snowfall [Unveiling the Right Side]
Written by Tan, I.-K. on February 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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Science and Culture in the 18th Century: Isaac Newton [Science in the Arts]
Written by Dominiczak, M. H. on February 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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An Appeal to Medical Journal Editors: The Need for a Full Description of Laboratory Methods and Specimen Handling in Clinical Study Reports [Editorials]
Written by Rifai, N., Annesley, T. M., Berg, J. P., Brugnara, C., Delvin, E., Lamb, E. J., Ness, P. M., Plebani, M., Wick, M. R., Wu, A., Delanghe, J. on February 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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Advancing Laboratory Medicine through Innovation: A Tale of Six Inventors [Special Report]
Written by Rifai, N., Diamandis, E. P., Lo, Y. M. D., Kricka, L. J., Wilding, P., Ladenson, J. H., Wittwer, C. T. on February 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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Mass Spectrometry in Biomarker Applications: From Untargeted Discovery to Targeted Verification, and Implications for Platform Convergence and Clinical Application [Opinions]
Written by Smith, R. D. on February 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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Breaking the Bottleneck in the Protein Biomarker Pipeline [Perspective]
Written by Witkowska, H. E., Hall, S. C., Fisher, S. J. on January 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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Comparison of Serum Creatinine and Cystatin C for Early Diagnosis of Contrast-Induced Nephropathy after Coronary Angiography and Interventions [Evidence-Based Medicine and Test Utilization]
Written by Ribichini, F., Gambaro, G., Graziani, M. S., Pighi, M., Pesarini, G., Pasoli, P., Anselmi, M., Ferrero, V., Yabarek, T., Sorio, A., Rizzotti, P., Lupo, A., Vassanelli, C. on January 28, 2012 – 8:01 pm -The diagnostic accuracy of serum creatinine and cystatin C (Cys) as early predictors of contrast-induced nephropathy (CIN) has been debated. We investigated the diagnostic sensitivities, diagnostic specificities, and variations from baseline for serum creatinine and Cys in CIN.
METHODS:We prospectively evaluated 166 patients at risk for CIN at baseline, and at 12, 24, and 48 h after exposure to contrast media. CIN occurred in 30 patients (18%). Changes () compared to baseline in serum creatinine and Cys were evaluated at the predefined time points. ROC curve analysis was performed for the 12-h basal serum creatinine and Cys.
RESULTS:The serum creatinine at 12 h from baseline was the earliest predictor of CIN [area under the ROC curve (AUC) = 0.80; P < 0.001]. The serum creatinine 15% variation [0.15 mg/dL (13.2 μmol/L)] yielded 43% diagnostic sensitivity and 93% diagnostic specificity. The Cys at 12 h from baseline performed significantly worse than serum creatinine (AUC = 0.48; P = 0.74).
CONCLUSIONS:Variations from the serum creatinine baseline offer better diagnostic accuracy for predicting CIN at an earlier stage than similar variations in Cys. An additional diagnostic value of Cys over the determination of serum creatinine in the setting of CIN was not observed.
Tags: chemistry, clinic
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Correction [Correction]
Written by on January 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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Diary [Unveiling the Right Side]
Written by Cacciatore, S. on January 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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American Old Master: The Art and Science of Thomas Eakins [Science in the Arts]
Written by Dominiczak, M. H. on January 28, 2012 – 8:01 pm -Tags: chemistry, clinic
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